5-Hydroxy Tryptamine (5-HT) Antagonists
5-Hydroxy Tryptamine (5-HT) Antagonists
1. Nonselective antagonists & partial agonists/antagonists
- Ergotamine
- Lysergic acid diethyl amide (LSD)
- 2-Bromo LSD
- Methysergide
- Cyproheptadine
- Cinnarizine
2. 5-HT2 Antagonists
- Ketanserin
- Ritanserin
- Clozapine
- Risperidone
3. 5-HT3 Antagonists
- Ondansetron
- Granisetron
- Tropisetron
- Palonosetron
- Ramosetron
Preparations
1. Ergotamine: 1 mg oral/sublingual, repeat as required (max. 6 mg), 0.25–0.5 mg s.c./i.m.; ERGOTAMINE 1 mg tab, 0.5 mg/ml inj. MIGRIL: Ergotamine 2 mg, caffeine 100 mg, cyclizine 50 mg tab. VASOGRAIN: Ergotamine 1 mg, caffeine 100 mg, paracetamol 250 mg, prochlorperazine 2.5 mg tab.
2. Dihydroergotamine (DHE): 2–6 mg oral (max. 10 mg/day), 0.5–1.0 mg i.m., s.c.;
DHE 1 mg tab, MIGRANIL 1 mg/ml inj.
3. Sumatriptan: 6 mg s.c., 50–100 mg oral at the onset of migraine attack, may be repeated once within 24 hours if required. Those not responding to the first dose should not be given the second dose; 25 mg nasal spray, may be repeated once after 2 hours; SUMINAT, SUMITREX 25, 50, 100 mg tabs, MIGRATAN 50, 100 mg tabs, SUMITREX-INJ KIT 6 mg in 0.5 ml inj.; also SUMINAT 25 mg per actuation nasal spray.
4. Rizatriptan: 5-10 mg at the onset of migraine attack, may be repeated after 2 hours if required.Those not responding to the first dose should not be given the second dose; RIZACT, RIZATAN 5 mg, 10 mg tabs.
5. Flunarizine: 10–20 mg OD, children 5 mg OD; NOMIGRAIN, FLUNARIN 5 mg, 10 mg caps/tab.
.png)
