H1 Antagonists

H1 Antagonists

(Conventional antihistaminics)

1. Highly sedative

• Diphenhydramine 
• Dimenhydrinate 
• Promethazine 
• Hydroxyzine 

2. Moderately sedative

• Pheniramine 
• Cyproheptadine 
• Meclozine 
• Cinnarizine

3. Mildly sedative

• Chlorpheniramine
• DexaChlorpheniramine
• Triprolidine
• Clemastine

4. Second generation (non sedating) antihistaminics

• Fexofenadine 
• Loratadine
• Desloratadine 
• Cetirizine 
• Levocetirizine 
• Azelastine 
• Mizolastine 
• Ebastine

Preparations 

Betahistine (Histaminergic agonist): 4–8 mg 6–8 hourly; VERTIN 8 mg tab. 

1. Diphenhydramine: 25–50 mg oral; BENADRYL 25 mg cap, 12.5 mg/5 ml syr. 

2. Dimenhydrinate: 25–50 mg oral, i.m.; DRAMAMINE 16 mg/5 ml syr, 50 mg tab, GRAVOL 50 mg tab. 

3. Promethazine: 25–50 mg oral, i.m. (1 mg/kg); PHENERGAN 10, 25 mg tab., 5 mg/ml elixer, 25 mg/ml inj. 

4. Hydroxyzine: 25–50 mg oral, i.m.; ATARAX 10, 25 mg tab., 10 mg/5 ml syr, 6 mg/ml drops, 25 mg/ml inj. 

5. Pheniramine: 20–50 mg oral, i.m.; AVIL 25 mg, 50 mg tab, 15 mg/5 ml syr, 22.5 mg/ml inj. 

6. Cyproheptadine: 4 mg oral; PRACTIN, CIPLACTIN 4 mg tab., 2 mg/5 ml syrup. 

7. Meclozine (Meclizine): 25–50 mg oral; In DILIGAN 12.5 mg + niacin 50 mg tab., In PREGNIDOXIN 25 mg + Caffeine 20 mg tab. 

8. Cinnarizine: 25–50 mg oral; STUGERON, VERTIGON 25 and 75 mg tab.

9. Chlorpheniramine: 2–4 mg (0.1 mg/kg) oral, i.m.; PIRITON, CADISTIN 4 mg tab. 

10. Dexchlorpheniramine: 2 mg oral; POLARAMINE 2 mg tab., 0.5 mg/5 ml syrup. 

11. Triprolidine: 2.5–5 mg oral; ACTIDIL 2.5 mg tab, ACTIFED 2.5 mg with pseudoephedrine 60 mg. 

12. Clemastine: 1–2 mg oral; TAVEGYL 1 mg tab., 0.5 mg/5 ml syr. 

13. Fexofenadine: 120–180 mg oral; ALLEGRA, ALTIVA, FEXO 120, 180 mg tab. 

14. Loratadine: 10 mg oral; LORFAST, LORIDIN, LORMEG, 10 mg tab, 1 mg/ml susp. 

15. Desloratadine: 5 mg oral; DESLOR, LORDAY, NEOLORIDIN 5 mg tab. 

16. Cetirizine: 10 mg oral; ALERID, CETZINE, ZIRTIN, SIZON 10 mg tab, 5 mg/5 ml syr. 

17. Levocetirizine: 5 mg oral; LEVORID, LEVOSIZ 5 mg, 10 mg tab, TECZINE, LEVOCET 5 mg tab, 2.5 mg/5 ml syr. 

18. Azelastine: 4 mg oral, 0.28 mg intranasal; AZEP NASAL SPRAY 0.14 mg per puff nasal spray.