Anticholinergic Drugs
Anticholinergic Drugs
(Muscarinic antagonists, Atropinic Drugs, Parasympatholytics)
1. Natural Alkaloids
- Atropine
- Hyosine (Scopolamine)
2. Semi synthetic derivatives
- Atropine methonitrate
- Homatropine
- Hyoscine butyl bromide
- Ipratropium bromide
- Tiotropium bromide
3. Synthetic compounds
a. Antisecretory-antispasmodics
i) Quaternary Compounds
- Propantheline
- Oxyphenonium
- Clidinium
- Pipenzolate methyl bromide
- Isopropamide
- Glycopyrrolate
ii) Tertiary amines
- Dicyclomine
- Valethamate
- Piprenzepine
b. Mydriatrics
- Cyclopentolate
- Tropicamide
c. Vasicoselective
- Oxybutylin
- Flavoxate
- Tolterodine
d. Antiparkinsonian
- Trihexyphenidyl (Benzhexol)
- Procyclidine
- Biperiden
Preparations
1. Atropine: 0.6–2.0 mg i.m./i.v. (Child 10 µg/kg), 1–2% topically in eye.
ATROPINE SULPHATE 0.6 mg/ml inj, 1% eye drop/oint, ATROSULPH 1% eye drop, 5% eye oint.
2. Hyoscine hydrobromide: 0.3–0.5 mg oral/i.m. (Child 10 µg/kg).
3. Hyoscine butyl bromide: 20–40 mg oral/i.m./s.c./i.v.
BUSCOPAN 10 mg tab, 20 mg/ml amp.
4. Atropine methonitrate: 2.5–10 mg oral/i.m.
MYDRINDON 1 mg (adult), 0.1 mg (child) tab; in SPASMOLYSIN 0.32 mg tab.
5. Propantheline: 15–30 mg oral. PROBANTHINE 15 mg tab.
6. Oxyphenonium: 5–10 mg (Child 3–5 mg) oral. ANTRENYL 5, 10 mg tab.
7. Clidinium: 2.5–5 mg oral. In SPASRIL, ARWIN 2.5 mg tab with chlordiazepoxide 5 mg. NORMAXIN, CIBIS 2.5 mg with dicyclomine 10 mg and chlordiazepoxide 5 mg tab.
8. Pipenzolate methyl bromide: 5–10 mg (Child 2–3 mg) oral. In PIPEN 5 mg tab. 4 mg/ml drops with dimethyl polysiloxane.
9. Isopropamide: 5 mg oral. In STELABID, GASTABID 5 mg tab. with trifluoperazine.
10. Dicyclomine: 20 mg oral.
CYCLOSPAS-D 20 mg with dimethicone 40 mg tab; CYCLOPAM INJ. 10 mg/ml in 2 ml, 10 ml, 30 ml amp/vial, also 20 mg tab with paracetamol 500 mg; in COLIMEX, COLIRID 20 mg with paracetamol 500 mg tab, 10 mg/ ml drops with dimethicone.
11. Valethamate: 8 mg i.m., 10 mg oral, repeated as required.
VALAMATE 8 mg in 1 ml inj, EPIDOSIN 10 mg tab, 8 mg inj.
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