Antirheumatoid Drugs
Antirheumatoid Drugs
1. Disease modifying anti-rheumatoid drugs (DMARDs)
a. Nonbiological drugs
i) Immuno-suppressants
- Methotrexate
- Azathioprine
- Cyclosporine
ii) Sulfasalazine
iii) Chloroquine
Hydroxychloroquine
vi) Leflunomide
b. Biological agents
i) TNF α-inhibitors
- Etanercept
- Infliximab
- Adalimumab
ii) IL-1 antagonist
- Anakinra
2. Adjuvant drugs
- Prednisolone and other glucocorticoides
Preparations
1. Chloroquine: 150 mg (base) per day; LARIAGO, RESOCHIN, NIVAQUIN-P 250 mg as phosphate (150 mg base) tab.
2. Hydroxychloroquine: initially 200 mg BD followed by 200 mg OD for maintenance;
ZHQUINE, ZYQ 200 mg tab.
3. Sulfasalazine: 1–3 g/day in 2–3 divided doses; SALAZOPYRIN, SAZO-EN 0.5 g tab.
4. Leflunomide: 100 mg/day for 3 days loading dose followed by 20 mg OD;
LEFRA 10 mg, 20 mg tabs.
5. Methotrexate: 7.5–15 mg weekly oral; NEOTREXATE, BIOTREXATE 2.5 mg tab.
6. Azathioprine: 50–150 mg/day; IMURAN 50 mg tab. 7. Etanercept: 25–50 mg s.c. once or twice weekly; ENBREL, ENBROL 25 mg/0.5 ml and 50 mg/1 ml inj.
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