Nonsteroidal antiinflammatory Drugs (NSAIDs)

1. Nonselective COX inhibitors

a. Salicylates

Aspirin

b. Propionic acid derivatives

Ibuprofen
Naproxen
Ketoprofen
Flurbiprofen

c. Fenamate

Mephenamic acid

d. Enolic acid derivatives

Piroxicam
Tenoxicam

e. Acetic acid derivatives

Ketorolac
Indomethacin
Nabumetone

f. Pyrazolone derivatives

Phenylbutazone
Oxyphenbutazone

2. Preferential COX-2 inhibitors

Nimesulide
Diclofenac
Aceclofenac
Meloxicam
Etodolac

3. Selective COX-2 inhibitors

Celecoxib
Etoricoxib
Parecoxib

4. Analgesic-antipyretics with poor antiinflammatory action

a. Para aminophenol derivative

Paracetamol (Acetaminophen)

b. Pyrazolone derivatives

Metamizol (Dipyrone)
Propiphenazone

c. Benzoxazocine derivative

Nefopam

Preparations

1. Aspirin: Antiinflammatory dose 3–5 g/day (75–100 mg/kg/day); analgesic-antipyretic dose 0.3–0.6 g 6–8 hourly; antiplatelet dose 75–150 mg/day. ASPIRIN 350 mg tab, COLSPRIN 100, 325 mg tabs, ECOSPRIN 75, 150, 325 mg tabs, DISPRIN 325 mg (with calcium carbonate 105 mg + citric acid 35 mg) tab, LOPRIN 75, 162.5 mg tabs. BIOSPIRIN: Lysine acetylsalicylate 900 mg + glycine 100 mg/vial for dissolving in 5 ml water and i.v. injection.

2. Indomethacin: 25–50 mg BD–QID. Those not tolerating the drug orally may be given nightly suppository. IDICIN, INDOCAP 25 mg cap, 75 mg SR cap, ARTICID 25, 50 mg cap, INDOFLAM 25, 75 mg caps, 1% eye drop. RECTICIN 50 mg suppository.

3. Ibuprofen: 400–800 mg TDS; BRUFEN, EMFLAM, IBUSYNTH 200, 400, 600 mg tab, IBUGESIC also 100 mg/5 ml susp.

4. Naproxen: 250 mg BD–TDS; NAPROSYN, NAXID, ARTAGEN, XENOBID 250 mg tab, NAPROSYN also 500 mg tab.

5. Ketoprofen: 50–100 mg BD–TDS; KETOFEN 50, 100 mg tab; OSTOFEN 50 mg cap. RHOFENID 100 mg tab, 200 mg SR tab; 100 mg/2 ml amp.

6. Flurbiprofen: 50 mg BD–QID; ARFLUR 50, 100 mg tab, 200 mg SR tab, FLUROFEN 100 mg tab, OCUFLUR 0.03% eye drops.

7. Mephenamic acid: 250–500 mg TDS; MEDOL 250, 500 mg cap; MEFTAL 250, 500 mg tab, 100 mg/5 ml susp. PONSTAN 125, 250, 500 mg tab, 50 mg/ml syrup.

8. Diclofenac: 50 mg TDS, then BD oral, 75 mg deep i.m.; VOVERAN, DICLONAC, MOVONAC 50 mg enteric coated tab, 100 mg S.R. tab, 25 mg/ml in 3 ml amp. for i.m. inj. DICLOMAX 25, 50 mg tab, 75 mg/3 ml inj. Diclofenac potassium: VOLTAFLAM 25, 50 mg tab, ULTRA-K 50 mg tab; VOVERAN 1% topical gel.

9. Aceclofenac: 100 mg BD; ACECLO, DOLOKIND 100 mg tab, 200 mg SR tab.

10. Piroxicam: 20 mg BD for two days followed by 20 mg OD; DOLONEX, PIROX 10, 20 mg cap, 20 mg dispersible tab, 20 mg/ml inj in 1 and 2 ml amps; PIRICAM 10, 20 mg cap.

11. Tenoxicam: 20 mg OD; TOBITIL 20 mg tab.

12. Ketorolac: 10–20 mg oral 6 hourly, 15–30 mg i.m./i.v. 6 hourly (max 90 mg/day); KETOROL, ZOROVON, KETANOV, TOROLAC 10 mg tab, 30 mg in 1 ml amp., KETLUR, ACULAR 0.5% eye drops.

13. Nimesulide: 100 mg BD; NIMULID, NIMEGESIC, NIMODOL 100 mg tab, 50 mg/5 ml susp.

14. Meloxicam: 7.5–15 mg OD; MELFLAM, MEL–OD, MUVIK, M–CAM 7.5 mg, 15 mg tabs.

15. Nabumetone: 500 mg OD; NABUFLAM 500 mg tab.

16. Etodolac: 200-400 mg BD-TDS; ETOVA 200, 300, 400 mg tabs.

17. Celecoxib: 100–200 mg BD; CELACT, CELCOX, COLCIBRA, COBIX 100, 200 mg tabs.

18. Etoricoxib: 60–120 mg OD; TOROCOXIA, ETOXIB, ETOSHINE, NUCOXIA 60, 90, 120 mg tabs.

19. Parecoxib: 40 mg oral/i.m./i.v. repeated after 6–12 hours (max. 80 mg/day);

PAROXIB 40 mg tab, REVALDO, VALTO-P 40 mg/vial inj.

20. Paracetamol: 325–650 mg (children 10–15 mg/kg) 3-5 times a day (max. 2600 mg/day); also 80–250 mg as suppository in infants and children; CROCIN 0.5 g tab, 125 mg/5 ml and 250 mg/5 ml syr, 100 mg/ml pediatric drops, CROCIN PAIN RELIEF 650 mg with caffeine 50 mg tab; METACIN, PARACIN 500 mg tab, 125 mg/5 ml syrup, 150 mg/ml ped. drops, ULTRAGIN, PYRIGESIC, CALPOL 500 mg tab, 125 mg/5 ml syrup, NEOMOL, FEVASTIN, FEBRINIL 300 mg/2 ml inj. JUNIMOL-RDS 80, 170, 250 mg suppository, PARACETAMOL RECTAL SUPPOSITORY 80, 170 mg.

21. Metamizol: 0.5–1.5 g oral/i.m./i.v.; ANALGIN 0.5 g tab; NOVALGIN, BARALGAN 0.5 g tab, 0.5 g/ml in 2 ml and 5 ml amps; ULTRAGIN 0.5 g/ml inj in 2 ml amp and 30 ml vial.

22. Propiphenazone: 300–600 mg TDS; marketed only in combination in several ‘over the counter’ preparations–in SARIDON, ANAFEBRIN: propiphenazone 150 mg + paracetamol 250 mg tab, DART: propiphenazone 150 mg + paracetamol 300 mg + caffeine 50 mg tab.

23. Nefopam: 30–60 mg TDS oral, 20 mg i.m. 6 hourly; NEFOMAX 30 mg tab, 20 mg in 1 ml amp.

Topical NSAIDs

1. Diclofenac 1% gel: VOLINI GEL, RELAXYL GEL, DICLONAC GEL

2. Ibuprofen 10% gel: RIBUFEN GEL

3. Naproxen 10% gel: NAPROSYN GEL

4. Ketoprofen 2.5% gel: RHOFENID GEL

5. Flurbiprofen 5% gel: FROBEN GEL

6. Nimesulide 1% gel: NIMULID TRANS GEL, ZOLANDIN GEL, NIMEGESIC-T-GEL

7. Piroxicam 0.5% gel: DOLONEX GEL, MOVON GEL, PIROX GEL, MINICAM GEL

Nonsteroidal antiinflammatory Drugs (NSAIDs)

Nonsteroidal antiinflammatory Drugs (NSAIDs)